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Drug: Acetaminophen

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Total 7876 results found since Jan 2013.

Hypotensive Response to IV Acetaminophen in Pediatric Cardiac Patients*
Conclusions: In isolation of other medication, a hemodynamic response to IV acetaminophen has a higher prevalence in critically ill children with cardiac disease than previously thought and justifies controlled studies in the perioperative and critical care setting. The added impact on individual patient hemodynamics and physiologic instability will require further study.
Source: Pediatric Critical Care Medicine - June 1, 2019 Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

Survey of Sedation and Analgesia Practice Among Canadian Pediatric Critical Care Physicians*
Conclusion: Our survey demonstrates great variation in practice in the management of pain and anxiety in Canadian PICUs. Standardized strategies for sedation, delirium and withdrawal, and sleep promotion are lacking. There is a need for research in this field and the development of evidence-based, pediatric sedation and analgesia guidelines.
Source: Pediatric Critical Care Medicine - September 1, 2016 Category: Pediatrics Tags: Feature Articles Source Type: research

Intermittent Versus Continuous and Intermittent Medications for Pain and Sedation After Pediatric Cardiothoracic Surgery; A Randomized Controlled Trial*
Objectives: Compare continuous infusions of morphine and midazolam in addition to intermittent doses with an intermittent only strategy for pain and sedation after pediatric cardiac surgery. Design: Randomized controlled trial. Setting: Advocate Children’s Hospital, Oak Lawn, IL. Patients: Sixty patients 3 months to 4 years old with early extubation after pediatric cardiac surgery. Interventions: Patients received a continuous infusion of morphine and midazolam or placebo for 24 hours. Both groups received intermittent morphine and midazolam doses as needed. Measurements and Main Results: Gender, age, by...
Source: Critical Care Medicine - December 19, 2017 Category: Emergency Medicine Tags: Pediatric Critical Care Source Type: research

Enteral Acetaminophen Bioavailability in Pediatric Intensive Care Patients Determined With an Oral Microtracer and Pharmacokinetic Modeling to Optimize Dosing
Conclusions: Microtracer studies present a new opportunity to gain knowledge on drug disposition in the intensive care. Using this modality in children in the pediatric intensive care, we showed that enteral administration of acetaminophen results in less predictable exposure and higher likelihood of subtherapeutic blood concentration than does IV administration. IV dosing may be preferable to ensure adequate pain relief.
Source: Critical Care Medicine - November 16, 2019 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Common topics in adolescent critical care medicine.
This article reviews some common conditions in adolescents that require critical care. Topics that are covered include severe sepsis and shock, acute respiratory distress syndrome, status asthmaticus, diabetic ketoacidosis, poisoning (acetaminophen, decongestants, prescription medications, selective serotonin reuptake inhibitors), and trauma. Comments about bariatric surgery are also included. PMID: 23705524 [PubMed - indexed for MEDLINE]
Source: Adolescent Medicine: State of the Art Reviews - December 20, 2015 Category: Pediatrics Tags: Adolesc Med State Art Rev Source Type: research

Analgesia in Neurocritical Care: An International Survey and Practice Audit*
Conclusions: Opiates and acetaminophen are preferred analgesic agents, and gabapentin is a contextual third choice, in neurocritically ill patients. Other agents are rarely prescribed. The discordance in physician self-reports and objective audits suggest that pain management optimization studies are warranted.
Source: Critical Care Medicine - April 16, 2016 Category: Emergency Medicine Tags: Neurologic Critical Care Source Type: research

Antipyretic Efficacy of Acetaminophen and Ibuprofen in Critically Ill Pediatric Patients
Objectives: To determine the antipyretic efficacy of acetaminophen (IV, enteral, rectal) and ibuprofen (enteral) in critically ill febrile pediatric patients. Design: Retrospective cohort study. Setting: Quaternary care pediatric hospital ICUs. Patients: Pediatric patients less than 19 years old who were febrile (≥ 38.0°C), received a dose of IV acetaminophen, enteral acetaminophen, rectal acetaminophen, or enteral ibuprofen and had at least one temperature measurement in the following 6 hours. Interventions: None. Measurements and Main Results: A total of 3,341 patients (55.8% male, median age 2.5 yr [...
Source: Pediatric Critical Care Medicine - August 1, 2019 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Medications for Children Receiving Intensive Care: A National Sample
Objective: To examine medication administration records through electronic health record data to provide a broad description of the pharmaceutical exposure of critically ill children. Design: Retrospective cohort study using the Cerner Health Facts database. Setting: United States. Patients: A total of 43,374 children 7 days old to less than 22 years old receiving intensive care with available pharmacy data. Interventions: None. Measurements and Main Results: A total of 907,440 courses of 1,080 unique medications were prescribed with a median of nine medications (range, 1–99; 25–75th percentile, 5–16...
Source: Pediatric Critical Care Medicine - September 1, 2020 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Can intravenous acetaminophen reduce the needs to more opioids to control pain in intubated patients ?
Conclusion: In our study, IV acetaminophen had no effect on decreasing the BPSs and need of morphine sulfate in intubated patients admitted to ICU.
Source: Indian Journal of Critical Care Medicine - August 10, 2016 Category: Intensive Care Authors: Babak Mahshidfar Azadeh Sameti Saeed Abbasi Davood Farsi Mani Mofidi Peyman Hafezimoghadam Popak Rahimzadeh Mahdi Rezai Source Type: research

N-acetylcystein in dengue associated severe hepatitis
We report a case of dengue hemorrhagic fever associated severe hepatitis (encephalopathy grade 2-drowsy and intermittent disorientation) treated with NAC resulted in good outcome without hepatic transplantation.
Source: Indian Journal of Critical Care Medicine - March 12, 2014 Category: Intensive Care Authors: Buddhika Widyaratna Peiris HabaragamuwaPalitha Dissanayaka Source Type: research

Hypotension Associated With IV Acetaminophen Administration in Pediatric Cardiac Patients
No abstract available
Source: Pediatric Critical Care Medicine - October 1, 2019 Category: Pediatrics Tags: Letters to the Editor Source Type: research

Nova StatStrip, a Hematocrit and Electrochemical Interference Correcting Clinical Glucometer, FDA Cleared
Nova Biomedical (Waltham, MA) won FDA clearance for its StatStrip Glucose Hospital Meter System, an accurate clinical level device for use anywhere from the neonatal ward to the intensive care unit. It is the first FDA-cleared device that has been cleared for blood sugar metering and management in all professional healthcare settings. The device measures hematocrit, the volume percentage of red blood cells that can affect glucose readings, and automatically corrects to provide an accurate result. Additionally, the device also adjusts for any electrochemical interference, including acetaminophen, ascorbic acid, and maltose...
Source: Medgadget Anesthesiology - September 30, 2014 Category: Anesthesiology Authors: Editors Tags: Anesthesiology Critical Care Medicine Pediatrics Source Type: news

Acetaminophen for Oxidative Injury in Severe SepsisAcetaminophen for Oxidative Injury in Severe Sepsis
Which patients benefit from acetaminophen within 24 hours of ICU admission for severe sepsis? Critical Care Medicine
Source: Medscape Today Headlines - April 10, 2015 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news

SCCM Pod-VCCR5 Rumack-Matthew Nomogram and Acetaminophen Toxicity
Sean P. Kane, PharmD, BCPS, speaks with Nadia Awad, PharmD, BCPS about Rumack-Matthew nomogram and acetaminophen toxicity. In the episode, the toxidrome of acetaminophen overdose is outlined and the nuances (including clinical practice pearls) are discussed regarding the nomogram used to decide whether N-acetylcysteine is warranted for acetaminophen toxicity.
Source: SCCM PodCast - iCritical Care - May 24, 2017 Category: Intensive Care Authors: The Society of Critical Care Medicine (SCCM) Tags: Medicine Source Type: podcasts